Emerging zoonotic viruses: new lessons on receptor and entry mechanisms.
Identifieur interne : 000193 ( France/Analysis ); précédent : 000192; suivant : 000194Emerging zoonotic viruses: new lessons on receptor and entry mechanisms.
Auteurs : Denis Gerlier [France]Source :
- Current opinion in virology [ 1879-6265 ] ; 2011.
Descripteurs français
- KwdFr :
- Animaux, Chiroptera (virologie), Humains, Infections à virus à ARN (génétique), Infections à virus à ARN (métabolisme), Infections à virus à ARN (virologie), Pénétration virale, Récepteurs viraux (génétique), Récepteurs viraux (métabolisme), Réservoirs d'agents pathogènes (virologie), Virus à ARN (génétique), Virus à ARN (physiologie), Zoonoses (virologie).
- MESH :
- génétique : Infections à virus à ARN, Récepteurs viraux, Virus à ARN.
- métabolisme : Infections à virus à ARN, Récepteurs viraux.
- physiologie : Virus à ARN.
- virologie : Chiroptera, Infections à virus à ARN, Réservoirs d'agents pathogènes, Zoonoses.
- Animaux, Humains, Pénétration virale.
English descriptors
- KwdEn :
- Animals, Chiroptera (virology), Disease Reservoirs (virology), Humans, RNA Virus Infections (genetics), RNA Virus Infections (metabolism), RNA Virus Infections (virology), RNA Viruses (genetics), RNA Viruses (physiology), Receptors, Virus (genetics), Receptors, Virus (metabolism), Virus Internalization, Zoonoses (virology).
- MESH :
- chemical , genetics : Receptors, Virus.
- genetics : RNA Virus Infections, RNA Viruses.
- metabolism : RNA Virus Infections, Receptors, Virus.
- physiology : RNA Viruses.
- virology : Chiroptera, Disease Reservoirs, RNA Virus Infections, Zoonoses.
- Animals, Humans, Virus Internalization.
Abstract
Viruses enter the host cell by binding cellular receptors that allow appropriate delivery of the viral genome. Although the horizontal propagation of viruses feeds the continuous emergence of novel pathogenic viruses, the genetic variation of cellular receptors can represent a challenging barrier. The SARS coronavirus, henipaviruses and filoviruses are zoonotic RNA viruses that use bats as their reservoir. Their lethality for man has fostered extensive research both on the cellular receptors they use and their entry pathways. These studies have allowed new insights into the diversity of the molecular mechanisms underlying both virus entry and pathogenesis.
DOI: 10.1016/j.coviro.2011.05.014
PubMed: 22440564
Affiliations:
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pubmed:22440564Le document en format XML
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Virus</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>RNA Virus Infections</term><term>RNA Viruses</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Infections à virus à ARN</term><term>Récepteurs viraux</term><term>Virus à ARN</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>RNA Virus Infections</term><term>Receptors, Virus</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Infections à virus à ARN</term><term>Récepteurs viraux</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus à ARN</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>RNA Viruses</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Chiroptera</term><term>Infections à virus à ARN</term><term>Réservoirs d'agents pathogènes</term><term>Zoonoses</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Chiroptera</term><term>Disease Reservoirs</term><term>RNA Virus Infections</term><term>Zoonoses</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Virus Internalization</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Pénétration virale</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Viruses enter the host cell by binding cellular receptors that allow appropriate delivery of the viral genome. Although the horizontal propagation of viruses feeds the continuous emergence of novel pathogenic viruses, the genetic variation of cellular receptors can represent a challenging barrier. The SARS coronavirus, henipaviruses and filoviruses are zoonotic RNA viruses that use bats as their reservoir. Their lethality for man has fostered extensive research both on the cellular receptors they use and their entry pathways. These studies have allowed new insights into the diversity of the molecular mechanisms underlying both virus entry and pathogenesis.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li></region></list><tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Gerlier, Denis" sort="Gerlier, Denis" uniqKey="Gerlier D" first="Denis" last="Gerlier">Denis Gerlier</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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